Washingtonpost. com_ common drugs may help alzheimer’s

Regular use of common anti-inflammatory drugs such as ibuprofen reduced the risk of Alzheimer’s disease by as much as 60 percent in a large group of elderly patients who took the medicine for two years, according to a study published yesterday. Alzheimer’s disease information The longer the drugs were taken the less the chance of getting Alzheimer’s disease, the study showed.

The study by medical and public health researchers at Johns Hopkins University points to the possibility of a simple method of preventing a disease that turns the golden years of 4 million Americans into a period of dementia, in which they often cannot carry on a simple conversation or recognize friends or loved ones.

History of alzheimer’s disease Alzheimer’s disease, in which the brain cells deteriorate, also is responsible for 100,000 deaths a year.

Although the study results are promising, researchers were quick to note that their findings come from studies in which patients’ medications and health were followed over a long time and links between disease and patients’ lives are analyzed from that data. Stages of alzheimer disease pdf They stress that the results need to be confirmed by strictly controlled studies that monitor the types of drugs that are used and set optimum doses.

Walter F. Characteristics of alzheimer’s disease Stewart of the Johns Hopkins School of Hygiene and Public Health, lead author of the study published in the journal Neurology, cautioned against immediately taking frequent doses of these non-steroidal anti-inflammatory drugs, known as NSAIDs, as a preventive measure against Alzheimer’s.

The medications, he said, are not designed for long-term use. Prognosis of alzheimer’s disease These drugs can cause serious side effects if taken too frequently and over a long period of time, said Stewart. Alzheimer’s disease definition Those side effects include gastric irritation and bleeding, peptic ulcers, impaired kidney function and kidney failure.

The most popular NSAID is ibuprofen (Advil, Motrin), which accounts for almost half of the reported use of this category of drugs. Alzheimer’s disease is caused by Ibuprofen’s use soared after 1980, when federal health officials approved its sale without a prescription. Diagnosis of alzheimer’s disease It is used commonly to relieve minor muscle pains, cramps and arthritis.

“To our knowledge this is the first study to demonstrate that increased duration of NSAID use is associated with a decreasing risk of Alzheimer’s disease,” the researchers said.

The Hopkins researchers, working with data gathered as part of a 39-year-old project of the National Institute on Aging known as the Baltimore Longitudinal Study on the Ages (BLSA), looked at records from more than 1,600 people that stretched back to 1980. The stages of alzheimer’s disease They began looking at patients using anti-inflammatory drugs because autopsy studies of the brains of Alzheimer’s patients indicated an inflammatory response was part of the disease.

“Many scientists now believe that inflammation may be an important component of the Alzheimer’s disease process,” said Claudia Kawas, a member of the Hopkins study team and clinical director of the Johns Hopkins Alzheimer’s clinic.

While NSAIDs show promise in preventing the onset of Alzheimer’s disease, Stewart and his fellow researchers were reluctant to say that one form of the medication is better than another. Alzheimer’s disease diagnosis They noted that they had only used past medical records and did not have strict clinical trials that assigned various drugs and doses to different patients and then evaluated the results. Alzheimer’s disease wiki He said scientists need to run studies testing the different kinds of NSAIDs to see which offers the best protection.

In addition, the researchers said clinical trials are needed to decide when the drugs should be used and what the proper dosage level should be.

The Hopkins researchers also looked at participants in the BLSA who had taken aspirin, also an anti-inflammatory drug, and acetaminophen (Tylenol), another pain-relieving medication with no anti-inflammatory properties. Alzheimer’s disease pictures They found that neither affected the risk of developing Alzheimer`s.

Stewart speculated that many of the participants in the BLSA were taking aspirin to prevent heart disease and took doses that were too small to have an impact on Alzheimer’s.

The research could not have been done without the BLSA, which since 1958 has studied “normal aging” in 2,300 people, the researchers said. How do you test for alzheimer disease All participants list the drugs they take and are examined by researchers for 2.5 days every two years. Early onset alzheimer’s disease Among those tests are close to a dozen that search for early signs of Alzheimer’s disease.