Researchers find that ‘peanut butter’ test can help diagnose alzheimer’s disease

Jennifer Stamps, a graduate student in the UF McKnight Brain Institute Center for Smell and Taste, and her colleagues reported the findings of a small pilot study in the Journal of the Neurological Sciences.

Stamps came up with the idea of using peanut butter to test for smell sensitivity while she was working with Dr. Treatment alzheimer’s disease Kenneth Heilman, the James E. Effects of alzheimer’s disease Rooks distinguished professor of neurology and health psychology in the UF College of Medicine’s department of neurology.

She noticed while shadowing in Heilman’s clinic that patients were not tested for their sense of smell.


Alzheimer’s disease pathology The ability to smell is associated with the first cranial nerve and is often one of the first things to be affected in cognitive decline. Alzheimer’s disease description Stamps also had been working in the laboratory of Linda Bartoshuk, the William P. Articles on alzheimer’s disease Bushnell presidentially endowed professor in the College of Dentistry’s department of community dentistry and behavioral sciences and director of human research in the Center for Smell and Taste.

In the study, patients who were coming to the clinic for testing also sat down with a clinician, 14 grams of peanut butter—which equals about one tablespoon—and a metric ruler. Is there a treatment for alzheimer’s disease The patient closed his or her eyes and mouth and blocked one nostril. Alzheimer’s disease association The clinician opened the peanut butter container and held the ruler next to the open nostril while the patient breathed normally. Alzheimer’s disease video The clinician then moved the peanut butter up the ruler one centimeter at a time during the patient’s exhale until the person could detect an odor. Late onset alzheimer’s disease The distance was recorded and the procedure repeated on the other nostril after a 90-second delay.

The clinicians running the test did not know the patients’ diagnoses, which were not usually confirmed until weeks after the initial clinical testing.

The scientists found that patients in the early stages of Alzheimer’s disease had a dramatic difference in detecting odor between the left and right nostril—the left nostril was impaired and did not detect the smell until it was an average of 10 centimeters closer to the nose than the right nostril had made the detection in patients with Alzheimer’s disease. Alzheimer’s disease symptoms and treatment This was not the case in patients with other kinds of dementia; instead, these patients had either no differences in odor detection between nostrils or the right nostril was worse at detecting odor than the left one.

Of the 24 patients tested who had mild cognitive impairment, which sometimes signals Alzheimer’s disease and sometimes turns out to be something else, about 10 patients showed a left nostril impairment and 14 patients did not. Alzheimer’s disease causes The researchers said more studies must be conducted to fully understand the implications.

“At the moment, we can use this test to confirm diagnosis,” Stamps said. First signs of alzheimer’s disease “But we plan to study patients with mild cognitive impairment to see if this test might be used to predict which patients are going to get Alzheimer’s disease.”

Stamps and Heilman point out that this test could be used by clinics that don’t have access to the personnel or equipment to run other, more elaborate tests required for a specific diagnosis, which can lead to targeted treatment. Alzheimer’s disease brain At UF Health, the peanut butter test will be one more tool to add to a full suite of clinical tests for neurological function in patients with memory disorders.

One of the first places in the brain to degenerate in people with Alzheimer’s disease is the front part of the temporal lobe that evolved from the smell system, and this portion of the brain is involved in forming new memories.

“We see people with all kinds of memory disorders,” Heilman said. Alzheimer’s disease prognosis Many tests to confirm a diagnosis of Alzheimer’s disease or other dementias can be time-consuming, costly or invasive. What are the physical symptoms of alzheimer disease “This can become an important part of the evaluation process.”