Ellison foundation invests $6 million in alzheimer’s disease research at uw _ uw hsnewsbeat

Precision medicine is the next wave in medical care. Alzheimer’s disease society In this approach, a patient is assessed genetically and in other ways for the treatments that will work best for their individual condition. Cure for alzheimer’s disease It’s a valuable concept, especially in complex conditions like Alzheimer’s disease.


“Alzheimer’s is driven by genetics, but it isn’t just one disease,” explains Dr. Dementia alzheimer’s disease Thomas Montine, the University of Washington’s chair of pathology and director of the UW Medicine Alzheimer’s Disease Research Center. Alzheimer’s disease is characterized by “It’s a disease that has many different subtypes, and one treatment won’t work for everyone. Pathophysiology of alzheimer’s disease Instead, the goal is to create multiple treatments and see which ones work best for each patient.”

With the Ellison Foundation’s gift, researchers at UW Medicine will take important steps in using precision medicine for Alzheimer’s disease: from understanding the genes and other factors that drive Alzheimer’s, to creating or finding drugs to treat it, and finally to understanding how different patients respond.

“We invested in this research because UW Medicine is uniquely equipped to succeed at it,” says Tom Ellison of the Ellison Foundation. Alzheimer’s disease genetic “Dr. Dementia and alzheimer’s disease Montine and his colleagues have done amazing work in Alzheimer’s, and their knowledge base will be key in creating the first part of the drug discovery pipeline.”

The drug discovery pipeline is shorthand for the years-long process of medical science: the work in the lab; the testing of potential drugs; FDA approval; and, finally, the prescription at the physician’s office. How long can you live with alzheimer’s disease With the Ellison Foundation’s gift — $6 million out of a $20 million project — UW Medicine intends to improve the drug pipeline by:

• Using exome sequencing to identify Alzheimer’s risk. What causes alzheimer disease 2013 UW Medicine’s Alzheimer’s Disease Research Center will use exome sequencing, a focused type of genomic sequencing, to test patients’ genes. Alzheimer’s disease medications Testing will help determine a patient’s risk of acquiring the disease.

• Testing more drugs, faster. Treatment for alzheimer’s disease Researchers will use patient-derived stem cells to test potential Alzheimer’s-defeating drugs at the Quellos High-throughput Screening Core at UW Medicine, a facility that allows fast and efficient testing.

• Recruiting a leader. Early signs of alzheimer disease may include UW Medicine will recruit a senior scientist to lead the clinical trials team, the group that will, eventually, test drugs in human volunteers.

• Finding Alzheimer’s earlier. The first stage of alzheimer disease is characterized by The gift also will help test the efficacy of an imaging tool called fMRI in detecting physiological changes in the brain — ones that may warn of impending Alzheimer’s — before dementia develops.

“The Ellison Foundation’s gift is giving us a wonderful start; they’re funding this first, essential phase of our project,” says Dr. 10 signs of alzheimer disease Paul Ramsey, CEO of UW Medicine. Physiological effects of alzheimer disease “When we know more about the genetics behind Alzheimer’s disease, and more about the drugs that may work on our patients, we’ll be able to move on to our second phase: drug testing in clinical trials. Alzheimer’s disease dementia And the impact will be global.”

The Ellison Foundation, headquartered in Bellevue, Wash., was established in 2003 by Tom and Sue Ellison. First stage of alzheimer disease is characterized by The foundation partners with innovative nonprofit organizations in medicine, education and human services.

UW Medicine’s mission is to improve the health of the public, and it does so by conducting ground-breaking research, providing a superb education to medical professionals, and providing exemplary care for patients in the Pacific Northwest region. Alzheimer disease smell test The organization’s work in Alzheimer’s research and care is part of a larger emphasis on promoting brain health and wellness. Stages of alzheimer’s disease Learn more at uwmedicine.org, or follow UW Medicine via Facebook and Twitter.