Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel_ further evidence for a new tumor entity – jul 27, 2016

Most mesenchymal neoplasms of the gastrointestinal tract belong to the category of gastrointestinal stromal tumors (GISTs) and are characterized by the immunohistochemical expression of KIT receptor. Reticulum cell sarcoma of the spleen icd 10 In cases without detectable KIT receptor expression several differential diagnoses have to be taken into consideration. Sarcoma tumor in cats Here, we report a case of a 41-year-old man with a tumor of the small bowel composed of large epithelioid tumor cells arranged in solid and alveolar sheets including scattered osteoclast-like multinucleated giant cells. Metastasized sarcoma Immunohistochemically, the tumor cells expressed strongly S-100 protein, vimentin, and to a lesser extent, bcl-2. Ewing sarcoma staging HMB-45, melan-A, KIT receptor, desmin, smooth-muscle actin, and CD-34 were not detectable.

Is sarcoma curable Ki-67 index was 20%. Sarcoma cell lines The diagnosis was established by 2 different FISH strategies demostrating the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of clear cell sarcoma of soft parts. Types of sarcoma in dogs Our results provide further evidence for the existence of a new tumor entity designated gastrointestinal clear cell sarcoma with osteoclast-like giant cells. Definition of sarcoma cancer The diagnosis of this entity should be considered in the presence of S-100-positive tumors of the gastrointestinal tract containing multinucleated giant cells and can be established by FISH analysis.

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